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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: J Immunol. 2014 Mar 3;192(7):3156–3165. doi: 10.4049/jimmunol.1301726

Figure 6. Neonatal and elderly mice do not upregulate important immune related pathways 24 hours following sepsis.

Figure 6

Heatmaps show the of gene expression of the functional category “Hematological Systems Development and Function” 24 hours following sepsis. Orange represents pathways with an over-expression of genes leading to the activation of the pathway, whereas blue represents pathways with an over-expression of genes whose activation will lead to down-regulation of the pathway. Neonatal mice have a large proportion of their pathways which are predominantly down regulated 24 hours after sepsis, which young the majority of young adult pathways are upregulated. Elderly mice fall in between. The corresponding tables show the top 10 pathways and their corresponding Z-score within the functional category 24 hours after sepsis. Red indicates that the pathway is significantly upregulated, whereas blue indicates that the pathway is significantly down regulated.