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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: J Immunol. 2014 Mar 3;192(7):3029–3042. doi: 10.4049/jimmunol.1302911

FIGURE 4.

FIGURE 4

WT BG1 and Rag−/− BG1 mice succumb to spontaneous relapsing-remitting CNS autoimmunity. (A) Incidence of first clinical signs of spontaneous EAE-like symptoms. Disease incidences are statistically different between WT BG1 (n=93) and Rag−/− BG1 (n=22) mice (p=0.003, log-rank test). No Gfap−/− BG1 mice (n=15) developed signs of disease symptoms. (B) Two examples of a clinical disease course for WT BG1 (open circle) and (C) Rag−/− BG1 mice (filled circle). Note, some of the Rag−/− BG1 mice did not survive to 180 day-old because of progressive disease.