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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: J Immunol. 2014 Mar 3;192(7):3029–3042. doi: 10.4049/jimmunol.1302911

FIGURE 8.

FIGURE 8

Viral activation of the naïve BG1 CD8 T cell induces CNS infiltration and autoimmunity. Vac:GFAP infection of C57BL/6 mice carrying small populations of BG1 CD8 T cells induces (A) atypical EAE disease symptoms and (B) weight loss. Each group consisted of 7–9 mice. For clarity, Standard Deviation error bars are shown only for mice receiving 2.5 × 105 BG1 CD8+ cells. (C) Identification of brain-resident BG1 CD8 T cell subsets following Vac:GFAP infection (see Fig. S1). (D) BG1 CD8 T cells present within the brain following Vac:GFAP activation are strong producers of IFNγ, and express (E) granzyme B. Phenotypic results are derived from or are a representative example of at least four individual mice. Error bars represent SEM. *; P=<0.05, **; P=<0.01, ns; Not Significant.