Table 3.
Bivariate correlations1 [r (P-values)] between number of plasma immune factors ≥ the LDC2 and neuropsychiatric symptom severity in adults with (HCV+) and without (HCV−) hepatitis C
| Total sample | HCV+ | HCV− | |
|---|---|---|---|
| Total N | 79 | 39 | 40 |
| Depression-Total (BDI-II), mean total scale score | 0.156 (0.173) | 0.258 (0.113) | −0.125 (0.448) |
| Depression-Cognitive Affective Factor (BDI-II), mean factor score | 0.077 (0.504) | 0.094 (0.568) | −0.003 (0.987) |
| Depression-Somatic Factor (BDI-II), mean factor score | 0.202 (0.078)*2001 | 0.365 (0.022)**2001 | −0.169 (0.310) |
| Anxiety (GADI), mean total scale score | 0.339 (0.003)***2001 | 0.357 (0.028)**2001 | 0.075 (0.651) |
| Fatigue (FSS), mean total scale score | 0.220 (0.057) | 0.144 (0.387) | 0.008 (0.964) |
| Pain Severity (BPI-PS), mean index score | 0.169 (0.142) | 0.150 (0.368) | 0.120 (0.466) |
| Pain Interference (BPI-PI), mean index score | 0.293 (0.010)***2001 | 0.345 (0.036)**2001 | 0.122 (0.461) |
BDI-II, Beck Depression Inventory-II; BPI-PI, Brief Pain Inventory-Pain Interference; BPI-PS, Brief Pain Inventory-Pain Severity; FSS, Fatigue Severity Scale; GADI, Generalized Anxiety Disorder Inventory; HCV+, adults with chronic hepatitis C virus infection; HCV−, adults with no history of infection with the hepatitis C virus; LDC, least detectable concentration; SD, standard deviation.
Spearman's rank correlations were used to assess the relationship between neuropsychiatric symptom severity and the number of immune factors that were ≥ LDC, within the total sample and by study group. Correlations are reported with P-values in parentheses.
The LDC is defined as the mean ± 3 standard deviations of 20 blank readings as provided by Myriad Rules Based Medicine.
*P < 0.100; **P < 0.050; ***P < 0.010.