(A) Results of the Main effect analyses of overestimation of one's empathic concern (red) and empathic concern itself (blue), superimposed on axial (z = −26) and coronal (y = 22, y = 3) slices of a whole-brain template derived from normal controls. Red-colored areas represent regions where atrophy negatively correlated with the discrepancy empathic concern score, adjusting for age, gender, Mini-Mental State Examination (MMSE), and total intracranial volume (TIV) (PFWE < 0.05). Blue-colored areas represent regions where atrophy positively correlated with the empathic concern score, adjusting for age, gender, MMSE, and TIV (PFWE < 0.05). (B). Results of the Main effect analyses of overestimation of one's empathic concern (red) and affective perspective taking (green), superimposed on axial (z = −29) and coronal (y = 22, y = 0) slices of a whole-brain template derived from normal controls. Red-colored areas represent regions where atrophy negatively correlated with the discrepancy empathic concern score, adjusting for age, gender, MMSE, and TIV (PFWE < 0.05). Green-colored areas represent regions where atrophy positively correlated with the affective perspective taking score, adjusting for age, gender, MMSE, and TIV (PFWE < 0.05).