Table 2.
Logistic regression analysis of the influence of childhood adversity factors and candidate genes on the probability of belonging to the MDD category.
| Adversities | Males |
Females |
||||
|---|---|---|---|---|---|---|
| P | OR | CI 95% | P | OR | CI 95% | |
| Abuse, neglect, and family dysfunction | 0.00* | 2.9 | 1.8–4.5 | 0.00* | 3.9 | 2.7–5.4 |
| Parental maladjustment | 0.01* | 2.3 | 1.2–4.5 | 0.06 | 1.7 | 0.9–3.0 |
| Life-threatening childhood physical illness | 0.02* | 2.3 | 1.1–4.6 | 0.03* | 2.2 | 1.1–4.6 |
| Parental death | 0.18 | 1.6 | 0.8–3.1 | 0.03* | 2.0 | 1.0–3.8 |
| Parental divorce/economic adversity | 0.60 | 1.1 | 0.7–1.8 | 0.98 | 1.0 | 0.7–1.4 |
| SCL6A4 SS genotype | 0.23 | 1.4 | 0.8–2.8 | 0.37 | 1.3 | 0.7–2.3 |
| BDNF Met + genotype | 0.13 | 2.3 | 0.8–3.5 | 0.69 | 1.6 | 0.6–2.3 |
BDNF, brain-derived neurotrophic factor; CI, confidence interval; MDD, major depression disorder; OR, odds ratio.
*
P < 0.05.