Table 2.

Meta-analysis GWAS results of 14-year long-term average composite depression measure of top findings (P < 10⁻⁵) in four NHS substudies (N = 6989).

SNP	Chr	Position	Allele 1/Allele 2	Allele 1 frequency	Closest gene	Approx. distance (kb)	Effect	Standard error	P-value
rs6763048	3	38656398	A/G	0.858	SCN5A	Intron	−0.076	0.016	8.42E-07
rs93239021	14	93641863	T/G	0.257	IFI27L1	3	−0.063	0.013	2.43E-06
rs108734471	14	93642502	A/T	0.748	IFI27L1	3.6	0.063	0.014	2.71E-06
rs4366580	13	22333062	T/C	0.200	IPMKP1	23	−0.062	0.013	3.90E-06
rs10512653	5	36474011	T/C	0.150	RANBP3L	136	0.069	0.015	4.08E-06
rs2529282	5	5564990	A/G	0.345	KIAA0947	21	0.052	0.011	4.43E-06
rs17287770	3	46629429	C/G	0.928	LOC100132146		−0.096	0.021	5.69E-06
rs26198552	5	5557842	T/C	0.653	KIAA0947	14	−0.051	0.011	7.40E-06
rs4266492	6	40803132	A/C	0.950	LRFN2	139	0.137	0.031	7.56E-06
rs7182961	15	60707884	C/G	0.749	TLN2	19	0.057	0.013	7.70E-06
rs2529302	5	5562703	A/C	0.339	KIAA0947	19	0.051	0.011	8.15E-06
rs2529292	5	5563450	T/C	0.339	KIAA0947	20	0.051	0.011	9.13E-06
rs26527152	5	5567517	A/G	0.659	KIAA0947	24	−0.051	0.011	9.16E-06
rs25785142	5	5574830	A/G	0.651	KIAA0947	31	−0.050	0.011	9.81E-06

GWAS, genome-wide association studies; NHS, Nurses' Health Study; SNP, single-nucleotide polymorphism.

¹SNPs in linkage disequilibrium with each other (r² > 0.8) on chromosome 14.

²SNPs in linkage disequilibrium with each other (r2 > 0.8) on chromosome 5.