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. Author manuscript; available in PMC: 2015 Feb 15.
Published in final edited form as: Bioorg Med Chem. 2014 Jan 8;22(4):1412–1420. doi: 10.1016/j.bmc.2013.12.065

Scheme 1.

Scheme 1

Synthetic routes for analogs 401, 402, 403, 404, and 406. Reagents and conditions: (a) methyl phenyl sulfoxide, LDA/THF; (b) triphenylphosphine, NBS/CH2Cl2; (c) K2CO3/DMF; (d) DIBAL-H/THF; (e) trifluoroacetic acid/CH2Cl2; (f) phenylacetyl chloride, NaHCO3/CH2Cl2.