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. Author manuscript; available in PMC: 2015 Feb 15.
Published in final edited form as: Bioorg Med Chem. 2014 Jan 8;22(4):1412–1420. doi: 10.1016/j.bmc.2013.12.065

Figure 5.

Figure 5

Ceramide analog 406 effectively eliminates drug-resistant cancer cells in ovarian and breast cancers. Error bars represent the standard errors of three independent experiments. Cells were treated with ceramide analogs for 72 h. *p <0.01 compared with in cells treated with analog 3. The IC50 values of analogs in each cell line are indicated. (A) Drug-sensitive OVCAR-8 human ovarian cancer cells. (B) Drug-resistant NCI/ADR-RES human ovarian cancer cells. (C) Drug-sensitive MCF-7 human breast cancer cells. (D) Drug-resistant MCF-7/Dox human breast cancer cells.