. Author manuscript; available in PMC: 2015 Feb 15.

Published in final edited form as: Bioorg Med Chem. 2014 Jan 8;22(4):1412–1420. doi: 10.1016/j.bmc.2013.12.065

Table 1.

IC₅₀ values for ceramide analogs in MTT viability assay (μM)

Compound	MCF-7	MDA-MB-231	MCF-7TN-R
	IC₅₀ (μM)
401	3.91 ± 1.51	17.23 ± 0.94	4.05 ± 1.30
402	26.44 ± 1.00	75.15 ± 0.88	9.91 ± 0.65
403	37.28 ± 2.45	51.23 ± 0.76	4.74 ± 1.07
404	233.6 ± 4.87	N.D.	28.96 ± 0.78
406	22.03 ± 1.52	161.4 ± 2.28	4.26 ± 1.48

MCF-7, MDA-MB-231, and MCF-7TN-R cells were treated with increasing concentrations of the analogs and studied for 24 h. The values are the mean ± SE of three independent experiments. N.D., not determined.