TABLE 6.
Odds ratios and 95% confidence intervals for glioma and meningioma and cumulative exposure to insecticides/herbicides, stratified by age (≤50 vs. >50 years), Phoenix, Arizona, Boston, Massachusetts, and Pittsburgh, Pennsylvania, 1994–1998
| Cumulative lifetime exposure (mg) |
Glioma |
Meningioma |
||||||
|---|---|---|---|---|---|---|---|---|
| No. of controls |
No. of cases |
Odds ratio |
95% confidence interval |
No. of controls |
No. of cases |
Odds ratio |
95% confidence interval |
|
| Men | ||||||||
| Inspecticides | ||||||||
| Up to 50 years of age | ||||||||
| Unexposed | 69 | 49 | 1.0* | 69 | 9 | 1.0* | ||
| >0–27 | 53 | 49 | 1.5 | 0.9, 2.6 | 53 | 5 | 0.8 | 0.2, 2.7 |
| >27 | 52 | 29 | 0.8 | 0.5, 1.5 | 52 | 1 | ||
| p = 0.22 | ||||||||
| Over 50 years of age | ||||||||
| Unexposed | 105 | 87 | 1.0* | 105 | 21 | 1.0* | ||
| >0–27 | 33 | 21 | 0.9 | 0.5, 1.8 | 33 | 3 | 0.5 | 0.1, 1.8 |
| >27 | 38 | 26 | 0.9 | 0.5, 1.6 | 38 | 7 | 0.9 | 0.3, 2.3 |
| p = 0.68 | p = 0.97 | |||||||
| Herbicides | ||||||||
| Up to 50 years of age | ||||||||
| Unexposed | 96 | 74 | 1.0* | 96 | 13 | 1.0† | ||
| >0–9.83 | 38 | 34 | 1.3 | 0.7, 2.2 | 38 | 2 | 0.5 | 0.1, 2.4 |
| >9.83 | 40 | 19 | 0.6 | 0.3, 1.2 | 40 | 0 | ||
| p = 0.11 | ||||||||
| Over 50 years of age | ||||||||
| Unexposed | 151 | 122 | 1.0* | 151 | 27 | 1.0† | ||
| >0–9.83 | 12 | 2 | 0.2 | 0.1, 1.1 | 12 | 2 | 1.6 | 0.3, 9.6 |
| >9.83 | 13 | 10 | 1.0 | 0.4, 2.4 | 13 | 2 | 0.4 | 0.1, 2.9 |
| p = 0.96 | p = 0.38 | |||||||
| Women | ||||||||
| Insecticides | ||||||||
| Up to 50 years of age | ||||||||
| Unexposed | 74 | 39 | 1.0‡ | 74 | 22 | 1.0§ | ||
| >0–19.8 | 79 | 39 | 0.9 | 0.5, 1.6 | 79 | 20 | 1.0 | 0.5, 2.0 |
| >19.8 | 60 | 13 | 0.4 | 0.2, 0.9 | 60 | 18 | 1.4 | 0.6, 2.9 |
| p = 0.02 | p = 0.36 | |||||||
| Over 50 years of age | ||||||||
| Unexposed | 116 | 60 | 1.0‡ | 116 | 47 | 1.0§ | ||
| >0–19.8 | 31 | 21 | 1.5 | 0.7, 3.0 | 31 | 17 | 1.4 | 0.7, 2.9 |
| >19.8 | 55 | 29 | 1.2 | 0.6, 2.2 | 55 | 25 | 1.2 | 0.6, 2.3 |
| p = 0.79 | p = 0.72 | |||||||
| Herbicides | ||||||||
| Up to 50 years of age | ||||||||
| Unexposed | 158 | 71 | 1.0‡ | 158 | 45 | 1.0§ | ||
| >0–1.25 | 32 | 14 | 1.1 | 0.5, 2.3 | 32 | 8 | 1.4 | 0.5, 3.5 |
| >27.125 | 23 | 6 | 0.6 | 0.2, 1.6 | 23 | 7 | 2.0 | 0.7, 5.9 |
| p = 0.27 | p = 0.21 | |||||||
| Over 50 years of age | ||||||||
| Unexposed | 186 | 95 | 1.0‡ | 186 | 71 | 1.0§ | ||
| >0–1.25 | 7 | 9 | 3.5 | 1.1, 10.9 | 7 | 8 | 5.2 | 1.4, 18.7 |
| >27.125 | 9 | 6 | 1.9 | 0.6, 5,9 | 9 | 10 | 3.9 | 1.2, 12.5 |
| p = 0.28 | p = 0.02 | |||||||
Adjusted for age (18–29, 30–39,40–49, 50–59, 60–69, 70–79, ≥80 years), hospital location (Phoenix, Boston, Pittsburgh), and proxy interview (yes/no).
Adjusted for age, hospital location, proxy interview, race (White, non-White), marital status (married/not married), and Jewish religion.
Adjusted for age, hospital location, proxy interview, marital status, and distance lived from hospital (0–5, >5–15, >15–30, >30—50, >50 miles). One mile = 1.61 km.
Adjusted for age, hospital location, proxy interview, race, marital status, Jewish religion (yes/no), and household income in $1,0005 (<15.0, 15.0–24.9, 25.0–34.9, 35.0–49.9, 50.0–74.9, ≥75.0).