Table 4.

The distribution of expression levels per IHC of proteins corresponding to ITGB-5, ITGA-3, MMP-2, MMP-9, and FN-1 ECM genes and EGFR, VEGF, KI-67, P53, and Bcl-2 molecules as per the degree of TNM staging of CRC (n = 114).

TNM tumor stage	EGFR		Total	P value
	High	Low
I + II				0.000
N	64	0	64
%	100.0%	0.0%	100.0%
III + IV
N	5	45	50
%	10.0%	90.0%	100.0%
Total
N	69	45	114
%	60.5%	39.5%	100.0%
TNM tumor stage	VEGF		Total	P value
	High	Low
I + II				0.186
N	27	37	64
%	42.2%	57.8%	100.0%
III + IV
N	28	22	50
%	56.0%	44.0%	100.0%
Total
N	55	59	114
%	48.2%	51.8%	100.0%
TNM tumor stage	KI-67		Total	P value
	High	Low
I + II				0.000
N	38	26	64
%	59.4%	40.6%	100.0%
III + IV
N	11	39	50
%	22.0%	78.0%	100.0%
Total
N	49	65	114
%	43.0%	57.0%	100.0%
Estadiamento	P53		Total	P value
	High	Low
I + II				0.000
N	35	29	64
%	54.7%	45.3%	100.0%
III + IV
N	11	39	50
%	22.0%	78.0%	100.0%
Total
N	46	68	114
%	40.4%	59.6%	100.0%
TNM tumor stage	Bcl-2		Total	P value
	High	Low
I + II				0.345
N	29	35	64
%	45.3%	54.7%	100.0%
III + IV
N	28	22	50
%	56.0%	44.0%	100.0%
Total
N	57	57	114
%	50.0%	50.0%	100.0%
TNM tumor stage	ITGB-5		Total	P value
	High	Low
I + II				0.000
N	49	15	64
%	76.6%	23.4%	100.0%
III + IV
N	14	36	50
%	28.0%	72.0%	100.0%
Total
N	63	51	114
%	55.3%	44.7%	100.0%
TNM tumor stage	ITGA-3		Total	P value
	High	Low
I + II				0.000
N	53	11	64
%	82.8%	17.2%	100.0%
III + IV
N	2	48	50
%	4.0%	96.0%	100.0%
Total
N	55	59	114
%	48.2%	51.8%	100.0%
TNM tumor stage	MMP-2		Total	P value
	High	Low
I + II				0.572
N	28	36	64
%	43.8%	56.3%	100.0%
III + IV
N	25	25	50
%	50.0%	50.0%	100.0%
Total
N	53	61	114
%	46.5%	53.5%	100.0%
TNM tumor stage	MMP-9		Total	P value
	High	Low
I + II				0.000
N	56	8	64
%	87.5%	12.5%	100.0%
III + IV
N	3	47	50
%	6.0%	94.0%	100.0%
Total
N	59	55	114
%	51.8%	48.2%	100.0%
TNM tumor stage	FN-1		Total	P value
	high	low
I + II				0.677
N	44	20	64
%	68.8%	31.3%	100.0%
III + IV
N	37	13	50
%	74.0%	26.0%	100.0%
Total
N	81	33	114
%	71.1%	28.9%	100.0%