Table 1.
Characteristics of broad and potent neutralizing antibodies to HIV-1
| Antibody Name | Site of Contact | Study | Antibody Type | Glycan dependence | Quaternary Structure dependence | Neutralization Breadth (%) | Infecting Subtype | Therapeutic Potential |
|---|---|---|---|---|---|---|---|---|
| IgG1b12 | CD4bs | Burton et al. (1991) Proc. Natl. Acad. Sci. USA; 88: 10134-10137 | Whole Antibody | No | No | 35 (n=190) | B | Effective against SHIV vaginal challenge and protects macaques. |
| VRC01,02,03 | CD4bs | Wu et al. (2010) Science329: 856-861 | Whole Antibody | No | No | 91, 91, 57 (n=190) | B | Effective against SHIV mucosal challenge and protects macaques. |
| NIH45-46 | CD4bs | Scheid et al. (2011) Science, 333: 1633-1637 | Whole Antibody | No | No | 96 (n=118) | B | Not tested |
| VRC-PG04 | CD4bs | Wu et al. (2011) Science; 333:1593-602 | Whole Antibody | No | No | 76 (n=178) | A-D recombinant | Not tested |
| 3BNC117 | CD4bs | Scheid et al. (2011) Science, 333: 1633-1637 | Whole Antibody | No | No | 96 (n=118) | B | Not tested |
| VHH J3 | CoRbs | McCoy, L. and Weiss, R. (2013). J Exp Med 210: 209-223. | Domain Antibody | NA | NA | 96 (n=100) | - | Not tested |
| m36 | CoRbs | Chen (2008) Proc Natl Acad Sci USA | Domain Antibody | No | No | 91 (n=11) | - | Not tested |
| 2008; 105: 17121-17126 | ||||||||
| 2G12 | Glycan | Trkola et al. (1996) J. Virol. 70: 1100-1108) | Whole Antibody | Yes | No | 32 (n=162) | B | Reduces viral load and increases CD4 T cell count in combination with 2F5, 4E10 |
| PGT121-123 | Glycan | Walker et al. (2011) Nature; 477:466-470) | Whole Antibody | Yes | No | 65-70 (n=162) | A | Not tested |
| PGT125-128,130-131 | Glycan | Walker et al. (2011) Nature; 477:466-470) | Whole Antibody | Yes | No | 40-72 (n=162) | CRF02_AG | Not tested |
| PGT135 | Glycan | Walker et al. (2011) Nature; 477:466-470) | Whole Antibody | Yes | No | 33 (n=162) | C | Not tested |
| PGT141-145 | Glycan | Walker et al. (2011) Nature; 477:466-470) | Whole Antibody | Yes | 38-78 (n=162) | A or D | Not tested | |
| PG9, PG16 | Quaternary structure including V1V2,V3 | Walker et al. (2009) Science 326: 285-289 | Whole Antibody | Yes | Yes | 79 and 73 (n=190) | A | Not tested |
| 2F5 | MPER | Purtscher et al. (1994) AIDS Res Human Retroviruses 10: 1651-1658 | Whole Antibody | No | No | 57 (n=177) | B | Tested in combination with 2G12. Help reduce viral load and increase CD4+ T cell count in HIV infected individuals. |
| 4E10 | MPER | Stiegler et al. (2001) AIDS Res. Hum. Retroviruses 17:1757-1765 | Whole Antibody | No | No | 98 (n=180) | B | Moderately suppresses viral load in combination with 2F5 |
| 10E8 | MPER | Huang et al (2012) Nature, 491: 406-412) | Whole Antibody | No | No | 98 (n=180) | B | Not tested |