Table 6.
Changes in structural proteins.
| SF | HS | 2G | |
|---|---|---|---|
| Upregulation | |||
| α‐actinin‐3 | * | – | – |
| α‐crystallin B chain | – | – | *,† |
| Cofilin‐2 | – | * | – |
| Isoform MLC1 of myosin light chain 1/3, skeletal muscle isoform | – | * | – |
| Isoform 1 of titin | – | *,† | – |
| Isoform 1 of tropomyosin α‐1 chain | *,† | – | – |
| Isoform 1 of tropomyosin β chain | * | – | – |
| Myomesin 2 | – | * | – |
| Myosin‐binding protein C, fast type | * | * | * |
| Myosin‐binding protein C, slow type | – | – | * |
| Myosin regulatory light chain 2, skeletal muscle isoform | – | * | – |
| Downregulation | |||
| α‐actinin‐2 | – | * | * |
| α‐crystallin B chain | *,† | – | – |
| Desmin | * | – | * |
| Isoform 1 of titin | *,† | – | *,† |
| Isoform 1 of tropomyosin α‐1 chain | – | *,† | – |
Significant responses of protein expressions to spaceflight (SF), hindlimb suspension (HS), or 2G exposure (2G) are indicated by *P < 0.05; −P > 0.05. The †indicates that the response of specific protein was opposite between each group.