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. 2014 Jan 14;3:27. doi: 10.1186/2193-1801-3-27

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© Tripathi et al.; licensee Springer. 2014

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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DLC1-mediated NF-κB suppression shows effects similar to sh(p65)NF-κB silencing or pharmacological down regulation of NF-κB. (A) Western blot showing NF-κB (p65) knock down, D1, D2, D3 and D4 are different clones. Clone D4 was taken for study. Microphotographs and/or quantitative valuation of Invasion Assay (B) Colony Formation (C) and Apoptosis Assay (D) of C4-2-B2 cells transduced with Lac Z or DLC1, stably transfected with shNF-κB or treated with NF-κB inhibitor (Peptide inhibitor 150 μM). (E) Western blot analysis of NF-κB-induced genes in cell extract from C4-2-B2 transduced and stably transfected with Ad-LacZ + sh-α-catenin, Ad-LacZ + sh-Neo, Ad-DLC1 + sh-α-catenin, Ad-DLC1 + sh-Neo, or NF-κB peptide inhibitor (150 μM).