Table 1.

Expression of phototransduction pathways genes, Wnt genes, and Circadian rhythm genes

		Breast cancer cell lines (Average signal)				Patients’ breast cancer tissues (1-8) (Average signal)
		MCF-7	T47D	MB-435	MB-231	1	2	3	4	5	6	7	8
Phototransduction genes
RHO	Rhodopsin	-45	27	31	87	-43	40	-63	14	-45	-90	13	-1
GRK1	Rhodopsin kinase	4.25	102	70	133.9
GNAT1 variant 1	Rod transducin alpha subunit	0	77	69	133	8	85	-12	54	31	4*	36	46
GNAT1 variant 2	Rod transducin alpha subunit	73	131*	90	124	54*	108	47**	63	60**	-7	75*	59
GNAT2	Cone transducin alpha subunit	27	93	83	248**	23	172**	-13	26	84**	-29	47	40
GNAZ	Cone transducin alpha subunit	199**	84	204**	118	139*	132**	131**	80**	255**	8*	250**	301
GNB1	Transducin beta subunit	22340**	14936**	14239**	17968**	20122**	20994**	17661**	15477**	21669**	19486**	20140**	17137**
GNB1L	Transducin beta subunit	925**	265**	1160**	1352**	607**	900**	1030**	261**	295**	749**	270**	343**
GNB2	Transducin beta subunit	2968**	675**	1208**	741**	1456**	691**	1171**	773**	3845**	1147**	1066**	1038**
GNG2L	Transducin beta subunit	69029**	73280**	43084**	56176**	62765**	50370**	70951**	65617**	74326**	62703**	59073**	25580**
GNB3	Transducin beta subunit	87*	95	136**	118	111*	117*	50**	179**	126**	23**	76**	96
GNB4	Transducin beta subunit	29	2157**	831**	1250**	229**	204**	687**	186**	288**	702**	565**	591
GNB5 variant 1	Transducin beta subunit	37	58	374**	217**	62**	85	58**	61	64**	17**	69	58
GNB5 variant 2	Transducin beta subunit	-7	54	31	106	19	73	-29	26	13	-61	7	41
GNGT1	Transducin gamma subunit	60	102	63	113	17	89	-24	63	25	-33	40	31
GNGT2	Transducin gamma subunit	-60	64	31	68	7	115	183**	74	15	93**	41	38
SAG	Arrestin	1	85	67	107	33	99	-44	107**	-1	14**	56	51
RLV1	Recoverin	-25	49	59	77	-21	63	7	60	32	-26	19	23
CNGA1	CNG channel alpha subunit	9	64	45	253	16	53	137**	10	139**	-50	30	15
CNGA2	CNG channel alpha subunit	3	76	65	97	4	71	-42	41	31	-41	49	33
CNGA3	CNG channel alpha subunit	-42	5	41	80	-29	66	-64	70	-30	-83	131**	145**
CNGB1	CNG channel beta subunit	13	23	27	81	6	74	-34	19	-7	-35	15	17
CNGB3	CNG channel beta subunit	14	43	44	95	10	93	-51	53	-18	-57	37	13
Wnt genes
WNT5A	Wnt	-31	10	293**	113	915**	670**	84**	490**	775**	266**	195**	267**
FZD2	Frizzled-2	864**	1740**	1828**	4896**	1213**	220**	1045**	1576**	1088**	620**	1176**	1186**
Circadian rhythm genes
PER1	Period 1	-25	69	53	80	32	100	-23	64	25	-1	62	102**
PER2 variant1	Period 2	7	56	59	93	-6	72	-31	32	21	-48	41	8
PER2 variant2	Period 2	5176**	2856**	1169**	846**	3847**	2745**	2693**	3234**	4415**	3693**	4735**	4683**
PER3	Period 3	4	64	49	89	6	73	-36	33	43	-12	77*	47
CLOCK	Clock	208**	330**	175**	216**	1001*	202*	364**	352**	575**	353**	468**	411*
TIMELESS	Timeless	5334**	8868**	3219**	4254**	2094**	1527**	1478**	2427**	1167**	2119**	1836**	1603**
CRY1	Cryptochrome 1	1302**	688*	682**	2693**	402**	1071**	474**	707**	326**	1205**	1052**	1166**
CRY2	Cryptochrome 2	2862**	1014**	494**	334**	1058**	908**	1622**	1611**	2053**	1604**	1171**	1078**

**P<0.01, *P<0.05, Significant values according to statistical variation for each gene probe analyzed on the Illumina array.