Table 3.

12-LOX Inhibition of Analogues 69–83^a

		12-LOX	15-LOX-1
compd	R	IC50 [± SD] (µM)	IC50 [± SD] (µM)	% inhb
69	Ph	4.5 [0.4]		49
70	1-naphthalene	1.6 [0.2]		70
71	2-benzothiazole	1.3 [0.2]	1.3 [0.2]
72	2-naphthalene	2.3 [0.3]		75
73	4-bi-Ph	4.2 [1.0]		73
74	8-isoquinoline	4.5 [0.8]		63
75	3-quinoline	5.3 [0.7]		58
76	4-piperidine-Ph	6.3 [3.0]		4
77	Ph	2.9 [0.4]		82
78	1-naphthalene	1.3 [0.3]		83
79	2-benzothiazole	1.7 [0.8]		100
80	3-quinoline	2.3 [0.5]		74
81	2-naphthalene	2.2 [0.3]		78
82	4-bi-Ph	2.5 [0.4]		80
83	8-quinoline	5.6 [2.0]		55

^aIC₅₀ values represent the half maximal (50%) inhibitory concentration as determined in the UV–vis cuvette-based assay in triplicate.

^bRepresents percent inhibition at 25 µM.