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. Author manuscript; available in PMC: 2014 Mar 27.
Published in final edited form as: J Med Chem. 2014 Jan 6;57(2):495–506. doi: 10.1021/jm4016476

Table 6.

In Vivo PK (Mouse) at 3 mpk (IV) and 30 mpk PO for 35a

compd routeb T1/2 (h) Tmax (h) Cmax (µM) AUCinf (µM·h) Vd (L/kg) Cl (mL/min/kg) %F MRTc
35 IV 3.4 NA 112 34 0.55 3.4 NA 2.44 h
PO 2.9 0.25 38 67 NA NA 19.8 NA
a

All experiments were conducted at Pharmaron Inc. using male CD1 mice (6–8 weeks of age). Data was collected in triplicate at 8 time points over a 24 h period.

b

Formulated as a solution (5% DMSO, 10% Solutol, 20% PEG400, 65% water).

c

Represents the time for elimination of 63.2% of the IV dose.