Table 6.
compd | routeb | T1/2 (h) | Tmax (h) | Cmax (µM) | AUCinf (µM·h) | Vd (L/kg) | Cl (mL/min/kg) | %F | MRTc |
---|---|---|---|---|---|---|---|---|---|
35 | IV | 3.4 | NA | 112 | 34 | 0.55 | 3.4 | NA | 2.44 h |
PO | 2.9 | 0.25 | 38 | 67 | NA | NA | 19.8 | NA |
All experiments were conducted at Pharmaron Inc. using male CD1 mice (6–8 weeks of age). Data was collected in triplicate at 8 time points over a 24 h period.
Formulated as a solution (5% DMSO, 10% Solutol, 20% PEG400, 65% water).
Represents the time for elimination of 63.2% of the IV dose.