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. Author manuscript; available in PMC: 2014 Nov 4.
Published in final edited form as: Mol Pharm. 2013 Sep 30;10(11):4120–4135. doi: 10.1021/mp400115y

Figure 4.

Figure 4

Proposed concept of a concentric-nuclear zone traversed by the polyplexes in the cell. The image was generated by compiling the two-dimensional confocal microscopy images and three dimensionally rendering the data allowing visualization of the nucleus (yellow) and polyplexes (blue). This image also shows an illustration of an intracellular three-dimensional concentric-nuclear zone (in blue-green) in the perinuclear space to help visualize how the “polyplex distance from the nucleus” was determined.