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. Author manuscript; available in PMC: 2014 Mar 27.
Published in final edited form as: Int J Dev Biol. 2009;53(0):707–716. doi: 10.1387/ijdb.072495ip

Fig. 4. Evolutionary conservation of a network subcircuit.

Fig. 4

The regulatory linkages between blimp1, otx, bra, foxA and gataE have been analyzed in sea urchin and starfish embryos. Most of the regulatory interactions between these genes are identical and are shown by solid lines. Otx expression is first induced by Blimp1 and is later on maintained by two positive feedback loops: Otx and one of its target genes, GataE, provide an input into otx. Otx together with GataE control the expression of bra and foxA. Interactions that are unique in one of the species are shown as dashed (sea urchin) or dotted (starfish) lines. Not conserved regulatory linkages include the auto-repression of blimp1 in sea urchin and the autoregulation of gataE in starfish. (Modified from Hinmann et al., 2003).