Table 6.
Univariate and multivariate analyses of factors associated with progression-free survival in 351 patients submitted to laparoscopic liver resection for hepatocellular carcinoma (HCC)
| Predictor of overall survival | n (%) | Univariate analysis |
Multivariate analysisa |
||
|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||
| AFP ≥200 ng/ml versus AFP <200 ng/ml | 60 (17%) | 1.6 (0.97–2.51) | 0.07 | ||
| Preoperative transarterial chemoembolization | 25 (7%) | 1.19 (0.58–2.45) | 0.64 | ||
| Major hepatectomy | 38 (11%) | 0.85 (0.49–1.49) | 0.57 | ||
| Pedicle clamping | 85 (24%) | 1.15 (0.8–1.66) | 0.45 | ||
| Blood transfusion requirement | 28 (8%) | 1.55 (0.86–2.8) | 0.15 | ||
| Cirrhosis | 247 (70%) | 2.03 (1.34–3.08) | 0.0008 | 2.3 (1.3–3.8) | 0.002 |
| Single versus multiple HCC | 302 (86%) | 2 (1.28–3.12) | 0.003 | ||
| Encapsulated HCC | 162 (46%) | 1.3 (0.91–1.85) | 0.15 | ||
| Satellite nodules | 81 (23%) | 1.98 (1.36–2.86) | 0.0003 | ||
| Poor versus good/moderate differentiation | 32 (9%) | 2.2 (1.33–3.6) | 0.0024 | 1.8 (1.1–2.9) | 0.004 |
| Vascular invasion | 119 (34%) | 1.75 (1.23–2.48) | 0.0017 | 2.1 (1.5–3.1) | <0.0001 |
| Tumour-free versus not tumour-free margin | 323 (92%) | 1.17 (0.54–2.51) | 0.69 | ||
a
Cox's regression model multivariate analysis included all variables with a P-value of <0.15 in univariate analysis.
HR, hazard ratio; 95% CI, 95% confidence interval; AFP, α-fetoprotein.