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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Nat Commun. 2014;5:2987. doi: 10.1038/ncomms3987

Fig. 8.

Fig. 8

Model explaining the function of MHF in the FA pathway of DNA damage repair. a, The MHF-FANCM (661-800) structure (PDB ID: 4DRB) is overlaid onto the tetramer 1 in the MHF-DNA complex (FANCM in red, MHF in green, and DNA in cyan). The ideal Holliday junction DNA is shown as sticks. The homology-modeled helicase domain of FANCM is shown as semi-transparent red contour. b, Model depicting a role of MHF (green) in facilitating FANCM (red) to branched DNA (purple) in FA pathway of DNA repair. The arm regions are also displayed before (as blue wires) or after (or blue tailed-tubes) DNA binding.