Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Mar 27;10(3):e1003507. doi: 10.1371/journal.pcbi.1003507

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Cockrell et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Panel A contains a histology cross section of ileal tissue (top) and scanning electron microscopy of the mucosal surface of ileum (bottom). These images are juxtaposed with Panel B, which is the topology used by SEGMEnT where crypts and villi are represented with a matrix of rectangular prisms. Each individual crypt or villus is then “unwrapped” onto a 2-dimensional grid (Panel C), on which signaling interactions, morphogen diffusion and physical cellular actions take place.