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Letter A depicts the cellular processes linked to Gut Epithelial Cell (GEC) type (Letter B), their spatial location in terms of the crypt-villus architecture (Letter C), and expected gradients of different morphogens (Letter D). Biologically realistic gradients for Wingless-related integration site (Wnt), Bone Morphogenetic Protein (BMP), Sonic Hedgehog Homolog (Hh), β-catenin, and Akt are shown.
