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. 2014 Mar 27;10(3):e1003507. doi: 10.1371/journal.pcbi.1003507

Figure 8. Normal and aberrant tissue response ischemia/reperfusion across a range of ischemic times.

Figure 8

With 30 minutes of ischemia (Panel A) there is minimal necrosis and the system returns to normal by ∼24 hrs. Increasing amounts of ischemia at 2 hrs (Panel B), 3 hrs (Panel C) and 4 hrs (Panel D) all demonstrate recoverable tissue architecture. With 5 hrs ischemia (Panel E) there is a persistent alteration in the tissue composition. Application of 6 hrs ischemia (Panel F) results in a non-recoverable injury. Panels G and H show corresponding behavior in the absence of sloughing (Panel G = 30 min ischemia, Panel H = 3 hrs ischemia). The lack of sloughing increases the number of necrotic cells in place, leading to increased inflammatory stimuli and the propagation of inflammation-mediated damage, converting readily recoverable ischemia at 30 minutes and 3 hrs to correspondingly persistent effects on the tissue architecture at 30 minutes ischemia (Panel G) and tissue necrosis with 3 hrs of ischemia (Panel H).