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. 2014 Mar 27;10(3):e1003526. doi: 10.1371/journal.pcbi.1003526

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© 2014 Teka et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Left: The spiking activity of the fractional model with a step current of 4 nA. Right: The inter-spike interval (ISI) curve of Layer 5 pyramidal neurons in primary motor cortex (Fig. 2B in [38]) is fitted with the ISI curve of the fractional model with (95% confidence interval with a least-squares fit). The first 7 ISIs of the model are removed for best fit. (B–C) Modeling the intrinsic memory of adapting pyramidal cells. (B) Left: The voltage trace of the model in response to a step current separated by 0.1 s inter-stimulus interval. Right: The ISIs of Cycle 1 and 5 as a function of ISI number. (C) The same as panel B, but with longer inter-stimulus interval, 2 s. For A–C . (D) Memory induced pauses of the model with depend on the magnitude of the current pulse. Left: Voltage traces with shorter and longer pauses in response to 1 nA and 4 nA current pulses, respectively. Right: The pause of the spiking activity increases as a function of the magnitude of the current pulse. For all we used ms and ms to better replicate the experimental data.

Inline graphic — (A) Left: The spiking activity of the fractional model with a step current of 4 nA. Right: The inter-spike interval (ISI) curve of Layer 5 pyramidal neurons in primary motor cortex (Fig. 2B in [38]) is fitted with the ISI curve of the fractional model with (95% confidence interval with a least-squares fit). The first 7 ISIs of the model are removed for best fit. (B–C) Modeling the intrinsic memory of adapting pyramidal cells. (B) Left: The voltage trace of the model in response to a step current separated by 0.1 s inter-stimulus interval. Right: The ISIs of Cycle 1 and 5 as a function of ISI number. (C) The same as panel B, but with longer inter-stimulus interval, 2 s. For A–C . (D) Memory induced pauses of the model with depend on the magnitude of the current pulse. Left: Voltage traces with shorter and longer pauses in response to 1 nA and 4 nA current pulses, respectively. Right: The pause of the spiking activity increases as a function of the magnitude of the current pulse. For all we used ms and ms to better replicate the experimental data.