FIGURE 5:

Expression of aptamers alters microtubule dynamics. (A) Number of adult flies expressing GFP-aptamer relative to number of balancer-carrying siblings that do not express GFP-aptamer (relative fly viability). The control has the identical genotype to experimental flies except that it does not carry aptamer transgenes. The relative viabilities of aptamer-expressing flies are significantly different from the control (p < 0.01, except for aptamer Perfect, which gives p = 0.02). (B) Microtubule growth rates at plus ends in hemocytes from third-instar larvae. Sibling larvae with or without expression of GFP-fused aptamer Perfect were compared. EB1-GFP driven by the ubiquitin promoter was used to mark growing microtubule plus ends. Error bars, SEM (n ≥ 146).