Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Possible mechanism for the nuclear accumulation of Rgf1p during replication stress in fission yeast. In nonstressed cells, Rgf1p enters the nucleus transiently. When cells are subject to replication stress, Rgf1p changes its conformation, probably by Cds1p phosphorylation, which allows its interaction with Rad24p. This remodeling would hide the NES, reducing its association with Crm1p and thus blocking its exit from the nucleus.
