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. 2014 Mar 27;9(3):e89449. doi: 10.1371/journal.pone.0089449

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© 2014 Grépin et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

To validate this method two phases are required. An ANALYTICAL PHASE: This phase concerns approximately twenty patients and is dedicated to the definition of an ideal decisional score considering the clinical/pathological and genetic parameters and in vitro/in vivo experiments. Based on this prospective study on a small number of patients, we observed a strict correlation between the cell and the patient response to a given drug with a success rate of 100% for our methodology, which aims at the determination of the most efficient treatment. If a strong correlation exists between our score and the success to the treatment a PROSPECTIVE PHASE will be envisaged. For this trial, treatments will be administered according to the best decisional score.