Table 2. Level of expression of the different receptors targeted by sunitinib and sorafenib.

	CSFR	FLT3	KIT	PDGFR	RET	VEGFR1	VEGFR2	VEGFR3	Score/8	E Score
786-O	100	100	100	100	100	100	100	100		800
	+	+	−	+	+	−	−	+	5
ccRCC	2	68	1284	139	100	112	5198	147		7050
	+	+	+	+	+	−	+	+	7
Met	6	145	11039	332	50	3274	1297	128		16271
	+	+	+	+	+	+	+	+	8

(−) indicates that no or very low levels of detectable amplified cDNA were observed on an agarose gel; (+) indicates amplified cDNA. The Score/8 indicates the presence of receptorsargeted by sunitinib or sorafenib. The E Score indicates the relative expression level as detected by quantitative and semi-quantitative PCR. A level of sensitivity to sunitinib similar to that of 786-O cells is indicated by a grey background; sensitivity only to higher concentrations of the drug is indicated by a black background.