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. 2014 Mar 27;9(3):e89449. doi: 10.1371/journal.pone.0089449

Table 3. Level of expression of the different receptors targeted by sunitinib and sorafenib.

CSFR FLT3 KIT PDGFR RET VEGFR1 VEGFR2 VEGFR3 Score/8 E Score
786-O 100 100 100 100 100 100 100 100 800
+ + + + + 5
2a 679 52 1914 4796 100 1026 15242 30 23839
+ + + + + + + 7
2b 576 38 550 2031 100 281 3162 16 6754
+ + + + + + + 7

(−) indicates that no amplified cDNA was detectable on an agarose gel; (+) indicates amplified cDNA. The Score/8 indicates the number of receptors targeted by sunitinib and sorafenib. The E Score indicates the relative expression level as detected by quantitative and semi-quantitative PCR.