Table 3. Level of expression of the different receptors targeted by sunitinib and sorafenib.
CSFR | FLT3 | KIT | PDGFR | RET | VEGFR1 | VEGFR2 | VEGFR3 | Score/8 | E Score | |
786-O | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 800 | |
+ | + | − | + | + | − | − | + | 5 | ||
2a | 679 | 52 | 1914 | 4796 | 100 | 1026 | 15242 | 30 | 23839 | |
+ | + | + | + | + | + | + | − | 7 | ||
2b | 576 | 38 | 550 | 2031 | 100 | 281 | 3162 | 16 | 6754 | |
+ | + | + | + | + | + | + | − | 7 |
(−) indicates that no amplified cDNA was detectable on an agarose gel; (+) indicates amplified cDNA. The Score/8 indicates the number of receptors targeted by sunitinib and sorafenib. The E Score indicates the relative expression level as detected by quantitative and semi-quantitative PCR.