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Astragaloside IV appear to block the cleavage of procaspase-8. As a result of the actions of Astragaloside IV, the release of Cyt c is inhibited, resulting in decreases of procaspase-9 and caspase-3. These activities lead to inhibition of apoptosis in hair keratinocyte. Fas/Fas L, Fas/Fas ligand; Cyt c, cytochrome c.
