Table 1.

Dosing regimens of rivaroxaban in adult patients for approved indications in the European Union and the US

Approved indications	European Union	US
Prevention of stroke and systemic embolism in patients with nonvalvular AF	20 mg od (15 mg od in patients with CrCl 15–49 mL/minute)	20 mg od (15 mg od in patients with CrCl 15–50 mL/minute)
VTE prevention after elective hip or knee replacement surgery	10 mg od	10 mg od
Treatment of DVT or PE	15 mg bid for 3 weeks 20 mg od thereafter	15 mg bid for 3 weeks 20 mg od thereafter
Prevention of recurrent DVT and PE	20 mg od	20 mg od
Prevention of atherothrombotic events in patients with ACS with elevated cardiac biomarkers*	2.5 mg bid	Not approved

Note:

^*Rivaroxaban is coadministered with acetylsalicylic acid alone or with acetylsalicylic acid plus clopidogrel or ticlopidine. Data from references 2 and 3.

Abbreviations: ACS, acute coronary syndrome; AF, atrial fibrillation; bid, twice daily; CrCl, creatinine clearance; DVT, deep vein thrombosis; od, once daily; PE, pulmonary embolism; US, United States; VTE, venous thromboembolism.