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. 2014 Mar 21;8:327–339. doi: 10.2147/DDDT.S55407

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© 2014 Li et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Tet protects RGCs from ischemic injury in vivo.

Notes: Effect of Tet on RGC survival in the central (A, D, G, J, M, and P), middle (B, E, H, K, N, and Q), and peripheral (C, F, I, L, O, and R) regions 1 day after retinal ischemia are shown. Injection of 2 μL of 10 μM Tet (A–C) 1 day before retinal ischemia reperfusion increased RGC survival in comparison to the PBS injection plus ischemia eyes (G–I), but did not reach the levels of Tet (J–L) and PBS (P–R) in nonischemic eyes. The GCL cell numbers in the Tet–I/R group were similar to those in the CNTF–I/R group. The ganglion cell layer (GCL), inner nuclear layer (INL), and outer nuclear layer (ONL) are indicated. Scale bar =50 μm (A–L). All images were taken at 60× magnification.

Abbreviations: CNTF, ciliary neurotrophic factor; GCL, ganglion cell layers; I/R, ischemia/reperfusion; PBS, phosphate-buffered saline; RGCs, retinal ganglion cells; Tet, tetrandrine.