Table 2.
Mean steady-state plasma concentrations of Tramadol following the once-daily administration of 200 mg of the formulation
| Parameter | Zytram XL® | Ultram® ER | Tridural® | Durela® |
|---|---|---|---|---|
| AUC0–24 (ng/mL) | NA | 5,975 | 5,991 | 6,600 |
| Cmax (ng/mL) | NA | 335 | 345 | 364 |
| Cmin (ng/mL) | NA | 187 | 157 | 165 |
| Tmax (hour) | NA | 12 | 4.0 | 9.7 |
Note: Zytram XL® (Purdue Pharma, Pickering, ON, Canada); Ralivia™ (Valeant Pharmaceuticals, Laval, QC, Canada, trade name Ultram® ER in the US); Tridural® (Labopharm Inc., Laval, QC, Canada); and Durela® (trade name Conzip™ in US), Cipher Pharmaceuticals Inc., Mississauga, Ontario, Canada.
Abbreviations: AUC0–24, area under curve; Cmax, peak plasma concentration; Cmin, minimum plasma concentration; Tmax, time to maximum concentration.