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. 2014 Mar 27;9(3):e93267. doi: 10.1371/journal.pone.0093267

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© 2014 Chen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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In two binding modes of PIIIA-Na_V1.4, Lys9 (A and B) and Arg14 (C and D) of the toxin protrudes into the filter of the channel, respectively. In (A) and (C), the Na⁺ ion inside the filter is shown as a yellow sphere. Toxin backbone is in yellow and channel backbone in grey.