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. 2014 Mar 27;9(3):e93216. doi: 10.1371/journal.pone.0093216

Table 2. Antimicrobial activity of cathelicidin-RC1 and cathelicidin-RC2.

Microorganisms MIC (μg/ml)
Cathelicidin-RC1 Cathelicidin-RC2 Meropenem Ampicillin
Gram-negative bacteria
Escherichia coli ATCC25922 4.69 (2.86 μM) >200 0.01 (0.03 μM) 4.69 (12.62 μM)
E. coli clinical strain 1 9.38 (2.86 μM) >200 0.12 (0.31 μM) 9.38 (25.24 μM)
E. coli clinical strain 2 18.75 (5.71 μM) >200 0.06 (0.15 μM) >200
E. coli clinical strain 3 18.75 (5.71 μM) >200 0.03 (0.08 μM) >200
E. coli clinical strain 4 18.75 (5.71 μM) >200 0.12 (0.31 μM) >200
Shigella dysenteriae clinical strain 4.69 (1.43 μM) >200 0.03 (0.08 μM) 75 (201.9 μM)
Klebsiella peneumoniae clinical strain 1 37.5 (11.43 μM) >200 0.06 (0.15 μM) >200
K. peneumoniae clinical strain 2 18.75 (5.71 μM) >200 0.06 (0.15 μM) >200
K. peneumoniae clinical strain 3 18.75 (5.71 μM) >200 0.06 (0.15 μM) >200
K. peneumoniae clinical strain 4 18.75 (5.71 μM) >200 0.06 (0.15 μM) >200
K. peneumoniae clinical strain 5 >200 >200 0.12 (0.31 μM) >200
K. peneumoniae clinical strain 6 37.5 (11.43 μM) >200 0.12 (0.31 μM) >200
K. peneumoniae clinical strain 7 37.5 (11.43 μM) >200 0.12 (0.31 μM) >200
K. peneumoniae clinical strain 8 75 (22.85 μM) >200 0.12 (0.31 μM) >200
Serratia marcescens clinical strain >200 >200 0.06 (0.15 μM) 37.5 (100.9 μM)
Klebsiella oxytoca clinical strain 4.69 (1.43 μM) >200 0.12 (0.31 μM) >200
Proteus vulgaris clinical strain >200 >200 0.23 (0.61 μM) 18.75 (50.49 μM)
Proteus mirabilis clinical strain 18.75 (5.71 μM) 150 (42.36 μM) 0.47 (1.22 μM) 75 (201.9 μM)
Acinetobacter baumannii clinical strain 1 >200 >200 0.23 (0.61 μM) 37.5 (100.9 μM)
A. baumannii clinical strain 2 >200 >200 0.23 (0.61 μM) 9.38 (25.24 μM)
Stenotrophomonas maltophilia clinical strain 1 37.5 (11.43 μM) >200 4.69 (12.22 μM) 18.75 (50.49 μM)
S. maltophilia clinial strain 2 9.38 (2.86 μM) 150 (42.36 μM) 4.69 (12.22 μM) >200
Pseudomonas aeruginosa ATCC27853 9.38 (2.86 μM) >200 0.06 (0.15 μM) >200
P. aeruginosa clinical strain 1 18.75 (5.71 μM) >200 0.06 (0.15 μM) 9.38 (25.24 μM)
P. aeruginosa clinical strain 2 4.69 (1.43 μM) >200 1.88 (4.89 μM) >200
Salmonella paratyphi A clinical strain 37.5 (11.43 μM) >200 0.12 (0.31 μM) >200
Gram-positive bacteria
Staphylococcus aureus ATCC25923 >200 >200 0.06 (0.15 μM) 9.38 (25.24 μM)
S. aureus clinical strain 1 9.38 (2.86 μM) >200 0.06 (0.15 μM) 18.75 (50.49 μM)
S. aureus clinical strain 2 9.38 (2.86 μM) >200 0.12 (0.31 μM) >200
S. aureus clinical strain 3 >200 >200 18.75 (48.9 μM) >200
S. aureus clinical strain 4 >200 >200 0.12 (0.31 μM) 9.38 (25.24 μM)
S. aureus clinical strain 5 4.69 (1.43 μM) >200 0.06 (0.15 μM) 9.38 (25.24 μM)
Bacillus cereus clinical strain >200 >200 0.06 (0.15 μM) >200
Bacillus subtilis clinical strain 9.38 (2.86 μM) >200 0.03 (0.08 μM) 75 (201.9 μM)
Enterococcus faecium clinical strain 9.38 (2.86 μM) >200 9.38 (24.45 μM) >200
Nocardia asteroides clinical strain 75 (22.85 μM) >200 4.69 (12.22 μM) 18.75 (50.49 μM)
Enterococcus faecalis clinical strain 75 (22.85 μM) >200 9.38 (24.45 μM) 37.5 (100.9 μM)
Staphylococcus epidermidis clinical strain 9.38 (2.86 μM) >200 0.94 (2.45 μM) >200
Fungi
Candida albicans clinical strain 1 9.38 (2.86 μM) >200 0.12 (0.31 μM) >200
C. albicans clinical strain 2 >200 >200 0.23 (0.61 μM) >200
C. albicans clinical strain 3 37.5 (11.43 μM) >200 0.06 (0.15 μM) >200
C. albicans clinical strain 4 9.38 (2.86 μM) >200 0.12 (0.31 μM) 18.75 (50.49 μM)
C. albicans clinical strain 5 >200 >200 0.06 (0.15 μM) >200
C. albicans clinical strain 6 >200 >200 0.03 (0.08 μM) >200
Candida glabrata clinical strain 1 9.38 (2.86 μM) >200 0.03 (0.08 μM) 18.75 (50.49 μM)
C. glabrata clinical strain 2 >200 >200 0.06 (0.15 μM) >200
Cryptococcus neoformans clinical strain >200 >200 0.47 (1.22 μM) 4.69 (12.62 μM)
Arcyria cinerea 18.75 (5.71 μM) >200 0.12 (0.31 μM) >200