Table 1. Three-dimensional structural alignment of viral OTU domains against selected structures in the Protein Data Bank using the DALI server [56].

DALI Query:	CCHFV OTU	DUGV OTU	TYMV PRO	EAV PLP2
	3PT2 [23]	4HXD [25]	4A5U [27], [28]	4IUM [26]
Human OTUD3	14.5; 12%*	14.4; 15%	7.6; 12%	4.2; 13%
4BOU [46]	2.1 Å (123)**	2.1 Å (123)	1.9 Å (85)	2.4 Å (69)
Yeast OTU1	11.8; 16%	11.6; 20%	7.3; 12%	5.1; 9%
3BY4 [57]	2.9 Å (126)	2.5 Å (123)	2.3 Å (91)	3.3 Å (81)
CCHFV OTU		28.1; 55%	6.8; 15%	4.6; 19%
3PT2 [23]		0.9 Å (157)	3.0 Å (91)	2.6 Å (74)
DUGV OTU			6.9; 12%	4.5; 19%
4HXD [25]			2.8 Å (90)	2.6 Å (74)
TYMV PRO				3.2; 13%
4A5U [27], [28]				2.8 Å (64)

*z-score (>2 indicates significant structural similarity [59]); % sequence identity.

**Root-mean-square deviation (RMSD) values are indicated, followed by the number of residues used for RMSD calculation in brackets. Value represents the average distance (Å) between alpha carbons used for comparison.