Figure 2. Neutralization of IL-22 after onset of arthritis reduces severity of arthritis.

A. 16 DBA mice were immunized with collagen and CFA. Mice with total score ≥1 and arthritis duration of ≥4 days were randomized to receive anti-IL-22 antibody (7–8 mice) or isotype control (7–8 mice) intraperitoneally at 100 ug/mouse/day for 10–12 days. Mice were scored for clinical arthritis every other day by a person blinded to interventions. Data shows cumulative arthritis score in 2 groups over time. Data shown is representative of 2 independent experiments. B. Histologic scoring of paws for various aspects of joint damage and inflammation assessed after H&E staining. Data is from 4 mice per group. C. Data shows the histology of hematoxylin and eosin staining of representative paws from the two groups of mice, magnification of 10×.