Figure 6. The protective effect of anti-IL-22 is reversed in IFN-γ deficient mice.
A: 16 female B6.129S7-ifngtm1Ts (B6.IFNγKO) mice were immunized with collagen and CFA. Mice with total score ≥1 and arthritis duration of ≥4 days were randomized to receive anti-IL-22 antibody (7–8 mice) or isotype control (7–8 mice) intraperitoneally at 100 ug/mouse/day for 8–9 days. Mice were scored for clinical arthritis every other day. Data shows cumulative arthritis score in 2 groups over time. B: Histologic scoring of paws for various aspects of joint damage and inflammation assessed after H&E staining. Data is from 4 mice per group. C: Hematoxylin and eosin staining of representative paws from the two groups of mice, magnification of 10×.