Table 3. [TIMP-2]*[IGFBP7] test characteristics at different cutoff values.

	Sensitivity	Specificity	PPV	NPV
Composite time*
0.3	0.92	0.66	0.73	0.88
0.4	0.92	0.67	0.75	0.99
0.5	0.92	0.81	0.80	0.90
0.6	0.81	0.83	0.84	0.80
0.7	0.81	0.91	0.91	0.81
4 h
0.3	0.80	0.83	0.80	0.83
0.4	0.62	0.88	0.84	0.68
0.5	0.54	0.92	0.86	0.65
0.6	0.46	0.92	0.86	0.61
0.7	0.46	1.0	1.0	0.63
12 h
0.3	0.85	0.50	0.65	0.75
0.4	0.77	0.75	0.77	0.75
0.5	0.65	0.83	0.81	0.69
0.6	0.58	0.92	0.88	0.67
0.7	0.54	0.92	0.88	0.65
24 h
0.3	0.73	0.58	0.66	0.67
0.4	0.62	0.75	0.73	0.64
0.5	0.58	0.83	0.79	0.65
0.6	0.42	0.88	0.79	0.58
0.7	0.27	0.96	0.88	0.55

* composite time: maximum urinary [TIMP-2]*[IGFBP7] concentration ((ng/ml)²/1000) achieved in the first 24 hours following surgery; PPV, positive predictive value; NPV, negative predictive value.