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. 2014 Mar 27;10(3):e1004033. doi: 10.1371/journal.ppat.1004033

Figure 2. IgE reactivity profiles of resistant and susceptible human cohorts to Schistosoma proteins printed on a proteome microarray.

Figure 2

Heatmap showing IgE responses of individual subjects (columns) in each cohort to 79 recombinant antigens (rows) printed on the microarray. Green represents no immunoreactivity through to red symbolizing strong immunoreactivity. The bar graph depicts the average signal intensity of each cohort. Proteins are ordered based on SI mean, highest to lowest, in the groups. Human cohorts represented: Putative Resistant (n = 20), CI-Light (n = 30), CI-Mod (n = 18) and CI-Heavy (n = 17) non-endemic Brazilian volunteers (n = 12), non-endemic North American volunteers (n = 12). The red line is the cut-off for reactivity, calculated as one standard deviation of the mean of the no-DNA control spots printed on the array and probed with anti-IgE. All of the proteins showed significant differences between at least two of the schistosome exposed groups (PR, CI-Light, CI-Mod and CI-Heavy) as calculated by Kruskal-Wallis test with Dunn's multiple comparison post-test (Table S4).