Table 1. Dependence of the Fibril Morphology and VCD on the Aggregation pH for Insulin, Lysozyme, apo-α-Lactalbumin, HET-s (218-289), and TTR (105-115) Fibrils.

protein, incubation conditions	pH region	morphology	VCD sign pattern	ΔA/A ∼1620 cm-1
insulin, 24 h at 70 °C	1.3–2.1	flat tape-like	reversed	0.15 × 10–4 to 0.18 × 10–4
	2.4–3.1	left-twisted	normal	–1 x10–4 to –3.5 × 10–4
lysozyme, 3 days at 65 °C	1.0–1.9	flat tape-like	reversed	0.9 × 10–2 to 1.7 × 10–2
	2.3	flat tape-like, left-twisted	normal, reversed	–2 × 10–4
	2.7	left-twisted	normal	–8 × 10–3
apo-α-lactalbumin, 3 days at 37 °C	1.5–2.5	left-twisted > flat tape-like	reversed	4.2 × 10–4 to 5.1 × 10–4
	3.0	flat tape-like	reversed	3.3 × 10–4
	4.0	flat tape-like	reversed	0.25 × 10–4
HET-s (218–298), 2 months at room temp	2.0	left-twisted	normal	–1.2 × 10–2
	3.3–3.9	flat tape-like	reversed	2.5 × 10–4 to 4.7 × 10–4
TTR (105–115), 2 days at 37 °C followed by 14 days at room temp	1.0–1.5	cylindrical, presumably left-twisted	normal	–0.5 × 10–4 to −1 × 10–4
	2.0–3.0	flat tape-like	reversed	2.5 × 10–4 to 7 × 10–4