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. 2014 Mar 27;9(3):e93544. doi: 10.1371/journal.pone.0093544

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© 2014 Scheinost et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) Several regions of the brain displayed evidence for both increased and decreased connectivity during the anesthesia state as detected by coupled-ICD. A follow-up seed-based analysis on independent data for one of these regions (the right parietal lobe; green region) revealed both significant (p<0.05 corrected) increases and decreases in connectivity to this region, echoing the coupled-ICD results. B) For some regions of the brain, coupled-ICD and conventional approaches showed seemingly conflicting results, with coupled-ICD suggesting decreased connectivity while conventional approaches suggest increased connectivity due to anesthesia. Seed connectivity for one of these regions (the left frontal lobe; green region) revealed both significant (p<0.05 corrected) increased and decreased connectivity, demonstrating that the different approaches may be sensitive to different aspects of changes in connectivity.