Table 1.
Docetaxel | Docetaxel and Dexamethasone |
Docetaxel and Efavirenz |
Docetaxel and Ketoconazole |
Docetaxel and Ritonavir |
|
---|---|---|---|---|---|
Cmaxa (μg/mL) | 18.1 ± 2.2 | 17.2 ± 3.9 | 25.5 ± 3.2 | 23.7 ± 2.1 | 43.5 ± 3.4 |
Fold vs. Control | - | 0.9 | 1.4 | 1.3 | 2.4 |
C24hra (μg/mL) | 0.009 ± 0.0007 | BLQ | 0.010 ± 0.003 | 0.009 ± 0.002 | 0.040 ± 0.005 |
Fold vs. Control | - | N.R. | 1.1 | 1.0 | 4.3 |
AUClast (μg*hr/mL) | 10.3 | 7.6 | 12.4 | 31.4 | 71.0 |
Fold vs. Control | - | 0.7 | 1.2 | 3.1 | 6.9 |
AUC0-∞ (μg*hr/mL) | 10.3 | 7.7 | 12.5 | 31.4 | N.R.b |
Fold vs. Control | - | 0.7 | 1.2 | 3.0 | N.R.b |
Cl (L/hr/kg) | 1.93 | 2.59 | 1.60 | 0.64 | N.Rb |
Terminal T1/2 (hr) | 6.4 | 4.9 | 4.7 | 3.5 | N.R.b |
For Cmax and C24hr, individual data is reported (n=3/cohort). For all other pharmacokinetic parameters, the results are from the average concentration-time profile.
Not reported due to >50% extrapolation of the AUC due to poor terminal disposition rate constant (λz).
Abbreviations: AUC0-∞, area under the concentration-time curve extrapolated to infinity; BLQ, below limits of quantitation; Cmax, maximum concentration; %C.V., percent coefficient of variation; Min, minimum; Max, maximum; St. Dev., standard deviation; Terminal T1/2, terminal half-life; Tmax, time to maximum concentration