Figure 4.

Nucleosome binding landscapes. (a) Graph depicting the unusual polar A/T-content distribution of the bacteriophage lambda genome along with the location of poly(dA-dT) tracts.³⁷ⁱ (b) Binding distributions of S. cerevisiae nucleosomes on the lambda phage genome. (Top) Binding landscape for the wild-type phage DNA,³⁷ⁱ and (bottom) distribution of nucleosomes on a lambda phage genome containing an engineered array of 13 tandem Widom 601 sequences (Unpublished results). (c) Comparison of canonical nucleosomes and H2AZ containing nucleosomes (combined data set) with nucleosomes containing the centromere specific histone H3 variant Cse4 (top) or nucleosomes assembled with both Cse4 and the nonhistone chaperone protein Scm3 (bottom).³⁷ⁱ Adapted with permission from ref (37i).