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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Obesity (Silver Spring). 2013 Dec 5;22(4):984–988. doi: 10.1002/oby.20647

Table 1.

SNPs with the lowest p values for association with a pre-diabetic trait.

Chr:SNP Gene R/NR allele AA change fR beta p value
Maximum recorded BMI (N=5,880, Sample 2+3)*$

18:rs7238987 CYB5A T/C P96P 0.30 0.024 6.2×10−7
1:rs913257 GORAB A/G K320E 0.87 0.022 2.7×10−4
12:120990399(novel) RNF10 C/T R151H 0.97 0.044 7.2×10−4

Maximum childhood z-score (N=5,316, Sample 2+3)§

12:120990399(novel) RNF10 C/T R151H 0.97 0.270 8.5×10−7
18:rs7238987 CYB5A T/C P96P 0.30 0.082 5.9×10−4

PFAT (N=555, Sample 1)#

18:rs7238987 CYB5A T/C P96P 0.32 2.039 7.0×10−6
2:rs6746030 SCN9A A/G W1150R 0.11 2.380 2.1×10−4
5:rs62624460 PCDHA8 G/C L64F 0.92 2.662 2.3×10−4
11:rs1064608 MTCH2 G/C A290P 0.5 1.453 3.1×10−4

Log10M (N=555, Sample 1)£

18:rs2282632 ASXL3 A/G N954S 0.12 −0.036 2.0×10−5
2:rs10804166 C2orf80 A/G S152G 0.15 −0.027 8.9×10−4

2-hr glucose (N=555, Sample 1)£

1:rs2890565 UTS2 C/T S98N 0.55 6.698 7.0×10−5
11:118244312(novel) UBE4A G/A P343L 0.96 17.154 2.7×10−4
19:rs16978738 ZNF225 T/A S679T 0.61 7.053 3.2×10−4
5:rs1432862 FAT2 A/G C574R 0.27 6.851 9.5×10−4

Log10AIR (N=297, Sample 1)¥

2:rs4674941 DOCK10 C/G I1251M 0.93 −0.144 2.8×10−4
7:rs2070607 OGDH G/A V1018I 0.92 −0.093 3.1×10−4
1:rs3176443 FAM5B C/G L390V 0.07 −0.140 5.0×10−4
17:rs12453124 KRT27 C/T E144K 0.43 −0.072 6.4×10−4

Log10 Disposition Index (N=297, Sample 1)¥

7:rs2070607 OGDH G/A V1018I 0.92 0.100 2.0×10−4
2:rs4674941 DOCK10 C/G I1251M 0.93 0.156 4.5×10−4
1:rs3176443 FAM5B C/G L390V 0.07 −0.141 5.0×10−4

R: risk allele, NR: non risk allele, fR: frequency of risk allele, BMI: body mass index, PFAT: percentage body fat, Log10M: logarithmic value of glucose disposal rate during insulin infusion, 2-hr glucose: 2-hour plasma glucose concentrations in response to a 75g OGTT, Log10AIR: Logarithmic value of acute insulin response to a 25g intravenous glucose bolus.

*

p values were adjusted for age, sex, birth year, nuclear family membership and estimate of admixture;

$

Maximum recorded BMI is defined as the highest BMI measured at a longitudinal exam when the subject was non-diabetic and ≥15 years of age;

§

maximum childhood z score is the highest age and sex adjusted Z score from an exam at age<20 yr, p values were adjusted for birth year, family membership and admixture.

#

p values were adjusted for age, sex and nuclear family membership;

£

p values were adjusted for age, sex, PFAT and nuclear family membership;

¥

analysis is restricted to full heritage Pima Indians who are normal glucose tolerant and p values were adjusted for age, sex, PFAT, nuclear family membership and Log10M (for AIR only).