Table 1.

SNPs with the lowest p values for association with a pre-diabetic trait.

Chr:SNP	Gene	R/NR allele	AA change	fR	beta	p value
Maximum recorded BMI (N=5,880, Sample 2+3)*$
18:rs7238987	CYB5A	T/C	P96P	0.30	0.024	6.2×10−7
1:rs913257	GORAB	A/G	K320E	0.87	0.022	2.7×10−4
12:120990399(novel)	RNF10	C/T	R151H	0.97	0.044	7.2×10−4
Maximum childhood z-score (N=5,316, Sample 2+3)§
12:120990399(novel)	RNF10	C/T	R151H	0.97	0.270	8.5×10−7
18:rs7238987	CYB5A	T/C	P96P	0.30	0.082	5.9×10−4
PFAT (N=555, Sample 1)#
18:rs7238987	CYB5A	T/C	P96P	0.32	2.039	7.0×10−6
2:rs6746030	SCN9A	A/G	W1150R	0.11	2.380	2.1×10−4
5:rs62624460	PCDHA8	G/C	L64F	0.92	2.662	2.3×10−4
11:rs1064608	MTCH2	G/C	A290P	0.5	1.453	3.1×10−4
Log10M (N=555, Sample 1)£
18:rs2282632	ASXL3	A/G	N954S	0.12	−0.036	2.0×10−5
2:rs10804166	C2orf80	A/G	S152G	0.15	−0.027	8.9×10−4
2-hr glucose (N=555, Sample 1)£
1:rs2890565	UTS2	C/T	S98N	0.55	6.698	7.0×10−5
11:118244312(novel)	UBE4A	G/A	P343L	0.96	17.154	2.7×10−4
19:rs16978738	ZNF225	T/A	S679T	0.61	7.053	3.2×10−4
5:rs1432862	FAT2	A/G	C574R	0.27	6.851	9.5×10−4
Log10AIR (N=297, Sample 1)¥
2:rs4674941	DOCK10	C/G	I1251M	0.93	−0.144	2.8×10−4
7:rs2070607	OGDH	G/A	V1018I	0.92	−0.093	3.1×10−4
1:rs3176443	FAM5B	C/G	L390V	0.07	−0.140	5.0×10−4
17:rs12453124	KRT27	C/T	E144K	0.43	−0.072	6.4×10−4
Log10 Disposition Index (N=297, Sample 1)¥
7:rs2070607	OGDH	G/A	V1018I	0.92	0.100	2.0×10−4
2:rs4674941	DOCK10	C/G	I1251M	0.93	0.156	4.5×10−4
1:rs3176443	FAM5B	C/G	L390V	0.07	−0.141	5.0×10−4

R: risk allele, NR: non risk allele, fR: frequency of risk allele, BMI: body mass index, PFAT: percentage body fat, Log₁₀M: logarithmic value of glucose disposal rate during insulin infusion, 2-hr glucose: 2-hour plasma glucose concentrations in response to a 75g OGTT, Log₁₀AIR: Logarithmic value of acute insulin response to a 25g intravenous glucose bolus.

^*p values were adjusted for age, sex, birth year, nuclear family membership and estimate of admixture;

^$ Maximum recorded BMI is defined as the highest BMI measured at a longitudinal exam when the subject was non-diabetic and ≥15 years of age;

^§ maximum childhood z score is the highest age and sex adjusted Z score from an exam at age<20 yr, p values were adjusted for birth year, family membership and admixture.

^# p values were adjusted for age, sex and nuclear family membership;

^£ p values were adjusted for age, sex, PFAT and nuclear family membership;

^¥ analysis is restricted to full heritage Pima Indians who are normal glucose tolerant and p values were adjusted for age, sex, PFAT, nuclear family membership and Log₁₀M (for AIR only).