Table 5.

Multinomial logistic regression results examining the risk of cognitive outcome by class, among 3,512 participants rated as cognitively normal at the time of assessment.

Diagnosis	Class 1	Class 2	Class 3	Class 4
	OR (95% CI) Wald X2, df, p-value	OR (95% CI) Wald X2, df, p-value	OR (95% CI) Wald X2, df, p-value	OR (95% CI) Wald X2, df, p-value
Normal	Reference	Reference	Reference	Reference
Impaired Not MCI	0.92 (0.41-1.85) 0.046, df=1, p=0.8298	1.62 (1.12-2.34) 6.65, df=1, p=0.0099	0.69 (0.47-1.01) 3.58, df=1, p=0.0584	0.38 (0.17-0.74) 6.78, df=1, p=0.0092
Amnestic MCI	2.71 (1.50-4.70) 11.91, df=1, p=0.0006	2.61 (1.82-3.75) 26.85, df=1, p<.0001	0.35 (0.22-0.53) 23.47, df=1, p<.0001	0.29 (0.12-0.59) 9.59, df=1, p=0.0020
Amnestic MCI plus‡	4.68 (2.78-7.70) 35.43, df=1, p<.0001	2.16 (1.47-3.16) 15.73, df=1, p<.0001	0.30 (0.18-0.48) 23.69, df=1, p<.0001	0.12 (0.04-0.29)† 16.89, df=1, p<.0001
Non-amnestic MCI, single domain	2.07 (0.78-4.81) 2.54, df=1, p=0.1107	2.32 (1.33-4.08) 8.72, df=1, p=0.0031	0.46 (0.24-0.85) 5.79, df=1, p=0.0161
Non-amnestic MCI, multiple domain‡	6.60 (2.18-18.46) 12.21, df=1, p=0.0005	1.44 (0.56-3.56) 0.62, df=1, p=0.4328	0.16 (0.03-0.57) 5.95, df=1, p=.0147
Dementia‡	7.74 (4.73-12.53) 68.01, df=1, p<.0001	1.80 (1.22-2.65) 8.92, df=1, p=0.0028	0.21 (0.12-0.35) 32.58, df=1, p<.0001	0.21 (0.06-0.52) 9.0, df=1, p=0.0027

Abbreviations: OR=Odds ratio; CI=Confidence Interval; MCI=Mild Cognitive Impairment

*Separate models were constructed for each class’ probability of multiple diagnostic outcomes. All models are adjusted for education, race, cardiovascular disease, hypertension, high cholesterol, diabetes, stroke or transient ischemic attack, and follow-up time (baseline age and sex were included in latent profile analysis).

^†Outcomes amnestic MCI multiple domain, non-amnestic MCI single and multiple domain were combined due to small numbers.

^‡Cochran-Armitage trend test across classes, 3 df, p<0.05