Table 4.

Adjusted ^aORs and 95 % CI for the effect of the interaction of candidate genes with lifestyle factors on the development of NAFLD (234 cases and 349 controls)

	Alcohol intake		Fruit intake		Grilled meat or fish intake
	Never drinkers	Males: <30 g Females: <20 g	0–2/day	>2/day	0–1/week	>1/week
GSTM1
Present	1.00	0.56 [0.29; 1.07]	1.00	3.06 [1.60; 5.84]	1.00	1.83 [0.96; 3.46]
Null	0.89 [0.48; 1.66]	0.56 [0.29; 1.07] p b = 0.081	0.77 [0.41; 1.45]	3.55 [1.88; 6.68] p < 0.001	0.68 [0.34; 1.36]	2.18 [1.18; 4.03] p = 0.013
GSTT1
Present	1.00	0.59 [0.35; 1.01]	1.00	4.23 [2.46; 7.29]	1.00	2.65 [1.54; 4.58]
Null	1.47 [0.71; 3.06]	0.85 [0.41; 1.76] p = 0.655	1.83 [0.89; 3.76] [−0.829; 0.732]	4.82 [2.26;10.32] p < 0.001	1.82 [0.82; 4.03] [−0.856;0.726]	3.26 [1.57; 6.79] p = 0.002
CYP1A1
CYP1A1*1/*1	1.00	0.55 [0.32; 0.94]	1.00	3.06 [1.80; 5.20]	1.00	2.37 [1.39; 4.04]
CYP1A1*2A carriers	0.92 [0.43; 1.99]	0.70 [0.34; 1.43] p = 0.326	0.72 [0.34; 1.53]	5.17 [2.37;11.27] p < 0.001	1.10 [0.48; 2.51] [−0.686; 0.779]	2.59 [1.25; 5.36] p = 0.011
CYP2E1 PstI
CYP2E1*1A/1A	1.00	0.62 [0.38; 1.00]	1.00	3.82 [2.34; 6.25]	1.00	2.23 [1.37; 3.62]
CYP2E1*5B carriers	0.92 [0.28; 3.08]	0.25 [0.06; 0.98] p = 0.046	0.68 [0.18; 2.58]	2.31 [0.71; 7.47] p = 0.163	0.41 [0.10; 1.71]	1.93 [0.59; 6.28] p = 0.273
CYP2E1 DraI
CYP2E1*1A/1A	1.00	0.56 [0.34; 0.92]	1.00	3.53 [2.14; 5.82]	1.00	2.38 [1.45; 3.91]
CYP2E1*6 carriers	1.09 [0.36; 3.32]	0.92 [0.22; 3.80] p = 0.911	0.52 [0.13; 2.05]	11.34 [2.70;47.55] p = 0.001	2.32 [0.37; 14.67] [−2.547; 1.682]	2.58 [0.95; 7.04] p = 0.063
SULT1A1
SULT1A1*1/*1	1.00	0.55 [0.30; 1.01]	1.00	4.05 [2.17; 7.53]	1.00	2.07 [1.12; 3.83]
SULT1A1*2carriers	1.04 [0.56; 1.94]	0.71 [0.36; 1.38] p = 0.314	1.28 [0.68; 2.42] [−0.697; 0.624]	4.18 [2.20; 7.94] p < 0.001	0.97 [0.48; 1.95]	2.69 [1.42; 5.10] p = 0.002

^aEstimates adjusted for age, sex, drinking habits, fruit, and grilled meat and fish

^b p for the interaction from logistic regression analysis