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. Author manuscript; available in PMC: 2014 Mar 28.
Published in final edited form as: Allergy Asthma Proc. 2011 Sep-Oct;32(5):359–365. doi: 10.2500/aap.2011.32.3460

Figure 4.

Figure 4

C-027 antagonizes histamine but not muscarinic-induced bronchoconstriction. Precision-cut lung slices containing a small human airway were pretreated with (A) C-027 (1.0 or 3.0 µM) for 2 hours. Airways were contracted with histamine. In separate studies, slices were pretreated with C-027 (3 µM) and (B) fexofenadine (3 µM) or (C) ipratropium (3 µM) and airways were contracted with the antagonist's respective agonist with no drug removal. (C) Pulmonary arterioles were contracted with 5-HT in the presence and absence of C-027 (3 µM). At least three airways or arterioles were used in each group from at least two human donors (therefore six airways total).